期刊
BIOMATERIALS
卷 30, 期 6, 页码 991-1004出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2008.10.061
关键词
Bone graft; Equine bone protein extract; BMP (bone morphogenetic protein); Gene expression; GeneChip
资金
- Chinese and Danish Governments [AM14:29NNP14]
- Ministry of Science and Technology of China [2005DFA30570]
- Guangdong Provincial Government [2005135030101]
- NSFC-Guangdong combined fund [u0732001]
- Zhuhai Municipal Government [PC20051068]
To elucidate the molecular mechanisms of spinal fusion with different graft materials during an anterior lumbar interbody fusion, we examined the gene-expression profiles after implantation of equine bone protein extract, rhBMP-2 and autograft using microarray technology and data analysis, including hierarchical clustering, self-organizing maps (SOM), KEGG pathway anti Biological process GO analyses in a porcine model. The results suggest that equine bone protein extract exhibited a more similar expression pattern with autograft than that of rhBMP-2. rhBMP-2 recruits progenitor cells, proliferation and differentiation possibly by inducing various factors including PGHS-2. IFGBP-2, VEGF and chemokines anti then leads to preferable membranous ossification anti bone remodeling. Conversely, equine bone protein extract results in endochondral ossification via upregulation of cartilage-related genes. Ossification by inducing direct osteoblastic differentiation and obviating the cartilaginous intermediate phases may increase spinal fusion rate. (C) 2008 Elsevier Ltd. All rights reserved.
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