期刊
BIOMATERIALS
卷 30, 期 5, 页码 843-849出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2008.10.037
关键词
Phospholipids; Gold nanoparticles; Liquid crystals; Proteins; Hydrophobic interactions
资金
- Ministry of Education AcRF Tier 1 [R279-000-205-112]
- National University of Singapore
- AUN/SEED-Net JICA
We report an easily visualized liquid crystal (LC)-based system to study the molecular interactions between protein-coated gold nanoparticles (AuNPs) and supported phospholipid monolayer self-assembled at the aqueous-LC interface. Protein-coated AuNPs were found to disrupt the phospholipid monolayer and resulted in the orientational transitions of LCs that support the phospholipid layer. The disruption of the phospholipid monolayer depends on the type of protein (albumin, neutravidin, and fibrinogen) adsorbing onto nanoparticles. Furthermore, our results suggest that hydrophobic interaction plays a major role in the disruption of the phospholipid layer by protein-coated AuNPs. Results obtained from this study may offer new understanding in the potential cytotoxicity of nanomaterials, where the interaction between nanoparticles and cell membrane is an important step. (C) 2008 Elsevier Ltd. All rights reserved.
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