期刊
BIOMATERIALS
卷 29, 期 35, 页码 4592-4597出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2008.08.021
关键词
Zwitterionic; Catechol; Protein adsorption; Bacterial adhesion; Biofilm; Nonfouling
资金
- China Scholarship Council
- Defense Threat Reduction Agency/Joint Science and Technology Office [HDTRA 1-07-1-0033]
- Office of Naval Research [N000140410409]
Biomimetic polymers with a zwitterionic moiety for ultra low fouling and a catechol end group for surface anchoring have been developed. Binding tests of the adhesive polymers on various surfaces, including amino (NH2), hydroxyl (OH), and methyl (CH3) terminated self-assembled monolayers (SAMs) along with bare gold, were performed under acidic and basic conditions. Protein adsorption from single protein solutions of fibrinogen, lysozyme, and complex media of 10-100% blood plasma and serum was measured using a surface plasmon resonance (SPR) sensor. Under optimized conditions, the coated surfaces are highly resistant to non-specific protein adsorption from both single protein solutions and blood serum/plasma. Furthermore, the 3-day accumulation of Pseudomonas aeruginosa on the coated surfaces was evaluated in situ in a laminar flow chamber. Results show that the coated surfaces are highly resistant to bacterial adhesion and biofilm formation. This work demonstrates a convenient and efficient method for using zwitterionic polymers with a catechol anchor group to achieve ultra low fouling surfaces via surface modification, for applications in complex media. (c) 2008 Elsevier Ltd. All rights reserved.
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