期刊
BIOMATERIALS
卷 29, 期 10, 页码 1526-1532出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2007.11.025
关键词
DNA; silica; surface modification; confocal microscopy; cell viability; drug delivery
资金
- NIBIB NIH HHS [R0I EB000244] Funding Source: Medline
Highly fluorescent core-shell silica nanoparticles made by the modified Stober process (C dots) are promising as tools for sensing and imaging subcellular agents and structures but will only be useful if they can be easily delivered to the cytoplasm of the subject cells. This work shows that C dots can be electrostatically coated with cationic polymers, changing their surface charge and enabling them to escape from endosomes and enter the cytoplasm and nucleus. As an example of cellular delivery, we demonstrate that these particles can also be complexed with DNA and mediate and trace DNA delivery and gene expression. (c) 2007 Published by Elsevier Ltd.
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