期刊
BIOMATERIALS
卷 29, 期 16, 页码 2548-2555出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2007.12.036
关键词
magnetic nanoparticle; fluorescence; nanohybrid; cancer; cetuximab
Cetuximab conjugated fluorescent magnetic nanohybrids (CET-FMNHs) were synthesized for detection of human epithelial cancer via magnetic resonance (MR) and optical imaging. Spherical FMNHs consist of MnFe2O4 magnetic nanocrystals encapsulated in pyrene-labeled PCL-b-PMAA as a surfactant prepared by a nano-emulsion method. FMNHs demonstrated excellent colloidal stability and biocompatibility for biomedical application. Antibody conjugated fluorescent magnetic nanohybrids (CET-FMNHs) served as effective agents for both magnetic resonance (MR) and fluorescence optical imaging of cancer cell lines. (c) 2008 Elsevier Ltd. All rights reserved.
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