期刊
BIOMATERIALS
卷 29, 期 26, 页码 3599-3608出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2008.05.018
关键词
star-shaped copolymer; micelle; photodynamic therapy; paclitaxel; cancer therapy
Amphiphilic 4-armed star-shaped chlorin-core diblock copolymers based on methoxy poly(ethylene glycol) (mPEG) and poly(E-caprolactone) (PCL) were synthesized and characterized in this study. The synthesized photosensitizer-centered amphiphilic star block copolymer that forms assembled micelle-like structures can be used in a photodynamic therapy (PDT)-functionalized drug delivery system. Moreover, the hydrophobic chemotherapeutic agent, paclitaxel, can be trapped in the hydrophobic inner core of micelles. In our results, the star-polymer-formed micelle exhibited efficient singlet oxygen generation, whereas the hydrophobic photosensitizer failed due to aggregation in aqueous solution. The chlorin-core micelle without paclitaxel loading exhibited obvious phototoxicity in MCF-7 breast cancer cells with 7 J/cm(2) or 14 J/cm(2) light irradiation at a chlorin concentration of 125 mu g/ml. After paclitaxel loading, the size of micelle increased from 71.4 nm to 103.2 nm. Surprisingly, these micelles were found to improve the cytotoxicity of paclitaxel significantly in MCF-7 cells after irradiation through a synergistic effect evaluated by median effect analysis. This functionalized micellar delivery system is a potential dual carrier for the synergistic combination of photodynamic therapy and chemotherapy for the treatment of cancer. Crown Copyright (c) 2008 Published by Elsevier Ltd. All rights reserved.
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