期刊
JOURNAL OF CRYSTAL GROWTH
卷 211, 期 1-4, 页码 122-136出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0022-0248(99)00819-2
关键词
particle technology; crystallization and precipitation; pharmaceuticals; solid drugs and excipients; supercritical carbon dioxide
Crystallization is a major technological process for particle formation in pharmaceutical industry and, in addition, plays an important role in defining the stability and drug release properties of the final dosage forms. Industrial and regulatory aspects of crystallization are briefly reviewed with reference to solid-state properties of pharmaceuticals. Crystallization, incorporating wider definition to include precipitation and solid-state transitions, is considered in terms of preparation of materials for direct compression, formation of amorphous, solvated and polymorphic forms. chiral separation of drugs, production of materials for inhalation drug delivery and injections. Finally, recent developments in supercritical fluid particle technology is considered in relationship to the areas discussed. (C) 2000 Elsevier Science B.V. All rights reserved.
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