期刊
CURRENT OPINION IN CELL BIOLOGY
卷 12, 期 2, 页码 174-179出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/S0955-0674(99)00073-3
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- NHLBI NIH HHS [HL4498, HL60178] Funding Source: Medline
- NIDDK NIH HHS [DK2173] Funding Source: Medline
The past eighteen months have provided much progress in the cyclic nucleotide phosphodiesterase (PDE) field. Six new phosphodiesterase genes have been discovered and characterized. In addition, several new highly specific PDE inhibitors have been developed and approved for clinical use. Finally, new strategies have been employed to determine PDE function in model systems including the use of antisense oligonucleotide and disruption techniques.
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