期刊
JOURNAL OF ANTIBIOTICS
卷 53, 期 4, 页码 345-350出版社
JAPAN ANTIBIOT RES ASSN
DOI: 10.7164/antibiotics.53.345
关键词
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A novel, potent and selective inhibitor of bacterial tyrosyl tRNA synthetase, designated SE-219383 has been isolated from Micromonospora sp. NCIMB 40684. The fermentation, isolation and some properties are described, whilst the structure determination is described in the succeeding paper(1)). SE-219383 showed competitive, inhibitory activity against a Staphylococcus tyrosyl tRNA synthetase, with an IC50 of <1 nM, and exhibited weak in vitro activity against some Streptococcus sp.
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