期刊
INTERNATIONAL JOURNAL OF OBESITY
卷 24, 期 4, 页码 485-491出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.ijo.0801183
关键词
testosterone; visceral adiposity; body fat distribution; diabetes mellitus; insulin resistance; Japanese Americans; computed tomography
资金
- NCRR NIH HHS [RR 00037] Funding Source: Medline
- NHLBI NIH HHS [HL 49293] Funding Source: Medline
- NIDDK NIH HHS [DK 31170] Funding Source: Medline
OBJECTIVE: To examine the association between baseline testosterone levels and changes in visceral adiposity in Japanese-American men. DESIGN: Prospective observational study. SUBJECTS: Second-generation Japanese-American males enrolled in a community-based population study. MEASUREMENTS: At baseline, 110 men received a 75 g oral glucose tolerance test (OGTT), and an assessment of body mass index (BMI); visceral adiposity measured as intra-abdominal fat area (IAF) using computed tomography (CT); fasting insulin and C-peptide levels; and total testosterone levels. IAF was re-measured after 7.5 y. Subcutaneous fat areas were also measured by CT in the abdomen, thorax and thigh. The total fat (TF) was calculated as the sum of IAF and total subcutanous fat areas (SCF). RESULTS: After 7.5 y, IAF increased by a mean of 8.0 cm(2) (95% CI: 0.8, 15.3). Baseline total testosterone was significantly correlated with change in IAF (r = -0.26, P = 0.006), but not to any appreciable degree with change in BMI, TF, or SCF. In a linear regression model with change in IAF as the dependent variable, baseline testosterone was significantly related to this outcome while adjusting for baseline IAF, SCF:, BMI, age, diabetes mellitus status (OGTT by the WHO diagnostic criteria) and fasting C-peptide (regression coefficient for baseline testosterone [nmol/l] = -107.13, P = 0.003). CONCLUSIONS: In this Japanese-American male cohort, lower baseline total testosterone independently predicts an increase in IAF. This would suggest that by predisposing to an increase in visceral adiposity, low levels of testosterone may increase the risk of type 2 diabetes mellitus.
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