期刊
JOURNAL OF VIROLOGY
卷 74, 期 7, 页码 3321-3329出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.74.7.3321-3329.2000
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A new human endogenous retrovirus (HERV) family, termed HERV-W, was recently described (J.-L. Blond, F. Beseme, L. Duret, O. Bouton, F, Bedin, H. Perron, B. Mandrand, and F, Mallet, J, Virol. 73:1175-1185, 1999), HERV-W mRNAs were found to be specifically expressed in placenta cells, and an env cDNA containing a complete open reading frame was recovered. In cell-cell fusion assays, we demonstrate here that the product of the HERV-W env gene is a highly fusogenic membrane glycoprotein, Transfection of an HERV-W Env expression vector in a panel of cell lines derived from different species resulted in formation of syncytia in primate and pig cells upon interaction with the type D mammalian retrovirus receptor. Moreover, envelope glycoproteins encoded by HERV-W were specifically detected in placenta cells, suggesting that they may play a physiological role during pregnancy and placenta formation.
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