期刊
PROSTAGLANDINS & OTHER LIPID MEDIATORS
卷 61, 期 1-2, 页码 29-41出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S0090-6980(00)00053-8
关键词
anandamide; metabolism; hepatocytes; macrophages; cyclooxygenase
资金
- NIDA NIH HHS [DA12178, DA09439, DA09017] Funding Source: Medline
In addition to the well studied hydrolytic metabolism of anandamide, a number of oxidative processes are also possible. Several routes somewhat analogous to the metabolism of free arachidonic acid have been reported. These involve mediation by various lipoxygenases and COX-2 and lead to ethanolamide analogs of the prostaglandins and HETES. The physiological significance of these products is not well understood at this time. There are also preliminary data suggesting a pathway involving oxidation of the hydroxy group of anandamide to a putative metabolite, N-arachidonyl glycine (AA-gly). This molecule displays activities in experimental models that suggest that it may play a role in some of the activities attributed to its precursor, anandamide. (C) 2000 Elsevier Science Inc. All rights reserved.
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