期刊
TOXICOLOGY
卷 144, 期 1-3, 页码 71-81出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/S0300-483X(99)00192-4
关键词
xenobiotic carbonyl metabolism; alcohol dehydrogenase; aldehyde dehydrogenase; carbonyl reduction; quinone reductase; hydroxysteroid dehydrogenase; aldo-keto reductases; short-chain dehydrogenases/reductases
The major metabolic pathways involved in synthesis and disposition of carbonyl and hydroxyl group containing compounds are presented, and structural and functional characteristics of the enzyme families involved are discussed. Alcohol and aldehyde dehydrogenases (ADH, ALDH) participate in oxidative pathways, whereas reductive routes are accomplished by members of the aldo-keto reductase (AKR), short-chain dehydrogenases/reductases (SDR) and quinone reductase (QR) superfamilies. A wealth of biochemical, genetic and structural data now establishes these families to constitute important phase I enzymes. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
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