期刊
CANCER LETTERS
卷 151, 期 1, 页码 25-29出版社
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3835(99)00409-7
关键词
apoptosis; mitochondria; cryptophycin; mitosis
类别
资金
- NCI NIH HHS [CA 23378] Funding Source: Medline
Exposure of murine leukemia L1210 cells to the antitumor antibiotic cryptophycin 52 (C52) led to cell-cycle arrest at the prometaphase/metaphase interface within 18 h, but apoptotic nuclei did not appear until 36 h later. To determine whether accumulation of cells in early metaphase might have delayed the apoptotic process, cells were treated with C52 for 18 h and a photodynamic process was used to initiate the release of mitochondrial cytochrome c. Apoptosis was observed within 60 min, indicating that the slow apoptotic response was not caused by an impaired ability of genomic DNA to undergo endonucleosomal cleavage during cell-cycle arrest induced by cryptophycin 52. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
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