期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 191, 期 7, 页码 1137-1148出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.191.7.1137
关键词
T cell receptor; CD28; absorption; internalization; antigen presenting cells
资金
- NCI NIH HHS [CA38355, CA25803] Funding Source: Medline
- NIAID NIH HHS [AI21487] Funding Source: Medline
At the site of contact between T cells and antigen-presenting cells (APCs), T cell receptor (TCR)-peptide-major histocompatibility complex (MHC) interaction is intensified by interactions between other molecules, notably by CD28 and lymphocyte function-associated antigen 1 (LFA-1) on T cells interacting with B7 (B7-1 and B7-2), and intracellular adhesion molecule I (ICAM-1), respectively, on APCs. Here, we show that during T cell-APC interaction, T cells rapidly absorb various molecules from APCs onto the cell membrane and then internalize these molecules. This process is dictated by at least two receptors on T cells, namely CD28 and TCR molecules. The biological significance of T cell uptake of molecules from APCs is unclear. One possibility is that this process may allow activated T cells to move freely from one APC to another and eventually gain entry into the circulation.
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