期刊
ORGANIC LETTERS
卷 2, 期 7, 页码 911-914出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol005555d
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资金
- PHS HHS [1R15 59594-01] Funding Source: Medline
[GRAPHICS] This paper describes the design, synthesis, and evaluation of transition metal complexes capable of recognizing flexible histidine-containing peptides in aqueous medium (25 mM HEPES buffer, pH = 7.0, 25 degrees C). When the pattern of metal ions on a complex matches with the pattern of histidine moieties on the peptide, strong interaction (K = 1.2 x 10(6) M-1) can be achieved. The complex was highly selective (>200:1) in discriminating similar flexible peptides differing only by one glycine unit.
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