期刊
ORGANIC LETTERS
卷 2, 期 7, 页码 1001-1004出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol005721h
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资金
- NIGMS NIH HHS [GM-59316] Funding Source: Medline
[GRAPHICS] The asymmetric ring opening of meso epoxides with TMSCN is catalyzed by (pybox)YbCl3 complexes, yielding the beta-trimethylsilyloxy nitrile ring-opened products with good enantioselectivities (83-92% ee). The reaction exhibits a second-order kinetic dependence on catalyst concentration and a first-order dependence on epoxide concentration, consistent with a bimetallic pathway involving simulataneous activation of epoxide and cyanide.
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