期刊
NEUROREPORT
卷 11, 期 5, 页码 1025-1030出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200004070-00026
关键词
adenosine; adenosine receptors; brain; testis
资金
- NINDS NIH HHS [R01-NS33539] Funding Source: Medline
An increasing number of reports suggest a role for A3 adenosine receptors (A3ARs) in mediating adenosine action in the central nervous system. However, studies of A3AR localization in the brain have yet to be performed. To provide insights into the central sites of A3AR action, we compared patterns of A1 and A3AR mRNA and binding site expression in the brains of rats, mice and humans. We also assessed whether A3 agonists are selective for A3ARs. Whereas it was possible to detect high-level A1AR expression in many brain regions, it was not possible to detect either A3AR gene or binding sire expression in the central nervous system. When we examined the affinities of the A3AR agonists Cl-IAB-MECA and IAB-MECA for A1ARs, we found that these compounds bound to AIARs with high affinity. These observations suggest that studies using A3-agonists need to consider potential effects of A1ARs activation, as A1ARs are abundantly expressed in the nervous system whereas A3AR expression in the brain cannot be directly demonstrated. NeuroReport 11:1025-1030 (C) 2000 Lippincott Williams & Wilkins.
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