期刊
FEBS LETTERS
卷 471, 期 1, 页码 23-28出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-5793(00)01332-6
关键词
peroxisome; peroxisomal membrane protein; Pmp22p; peroxisomal membrane targeting; membrane targeting signal
Investigating targeting of the 22 kDa peroxisomal membrane protein (Pmp22p) to the peroxisomal membrane we have confined the targeting signal to amino acid residues 16-37 located in the N-terminal cytoplasmic tail, Comparison of Pmp22p orthologous sequences revealed a conserved motif Y3xL3xP3x(KQN) which might represent the core of this targeting signal not found so far in other Pmps. Fusion of the Pmp22p N-terminal tail to the C-terminal portion of Pmp22p which per se is not targeted to peroxisomes, conveys peroxisomal targeting, These data suggest that Pmp22p is targeted to peroxisomes by a new membrane targeting signal which is necessary and sufficient to target a polypeptide containing two transmembrane spans to peroxisomes. (C) 2000 Federation of European Biochemical Societies.
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