期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 97, 期 8, 页码 4321-4326出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.97.8.4321
关键词
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资金
- NIDA NIH HHS [R37 DA007348, DA07348, R01 DA007348] Funding Source: Medline
The conditioning of the pharmacological actions of cocaine with environmental stimuli is thought to be a critical factor in the longterm addictive potential of this drug. Cocaine-related stimuli may increase the likelihood of relapse by evoking drug craving, and brain-imaging studies have identified the amygdala and nucleus accumbens (NAcc) as putative neuroanatomical substrates for these effects of cocaine cues. To study the significance of environmental stimuli in the recovery of extinguished cocaine-seeking behavior, male Wistar rats were trained to associate discriminative stimuli (S Delta s) with response-contingent availability of intravenous cocaine vs. saline. The rats then were subjected to repeated extinction sessions during which cocaine, saline, and the respective S Delta s were withheld until the animals reached an extinction criterion of less than or equal to 4 responses over three consecutive sessions. Subsequent re-exposure to the cocaine S Delta, but not the nonreward S Delta, produced strong recovery of responding at the previously active lever in the absence of any further drug availability. The efficacy and behavioral selectivity of the cocaine S Delta remained unaltered throughout an I-day test period. Exposure to the cocaine S Delta significantly increased dopamine efflux in the NAcc and amygdala as measured by intracranial microdialysis in a separate group of rats, Dopamine levels remained unaltered in the presence of the nonreward S Delta. The results demonstrate that cocaine-predictive stimuli elicit robust and persistent cocaine-seeking behavior, and that this effect may involve activation of dopamine transmission in the NAcc and amygdala.
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