期刊
BIOCHEMICAL JOURNAL
卷 347, 期 -, 页码 321-337出版社
PORTLAND PRESS LTD
DOI: 10.1042/0264-6021:3470321
关键词
endobiotic metabolism; gene expression; gene transcription; ligand-activated; xenobiotic metabolism
Members of the nuclear-receptor superfamily mediate crucial physiological functions by regulating the synthesis of their target genes. Nuclear receptors are usually activated by ligand binding. Cytochrome P450 (CYP) isoforms often catalyse both formation and degradation of these ligands. CYPs also metabolize many exogenous compounds, some of which may act as activators of nuclear receptors and disrupters of endocrine and cellular homoeostasis. This review summarizes recent findings that indicate that major classes of CYP genes are selectively regulated by certain ligand-activated nuclear receptors, thus creating tightly controlled networks.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据