期刊
JOURNAL OF IMMUNOLOGY
卷 164, 期 8, 页码 3950-3954出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.164.8.3950
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- NIAID NIH HHS [1F32AI0249-01A1, AI30048] Funding Source: Medline
- NINDS NIH HHS [NS21496] Funding Source: Medline
Bcl-2 plays a critical role in regulating cell survival and apoptosis, We examined Bcl-2 expression in virus-specific CD8 T cells during the expansion, death, and memory phases of the T cell response following infection of mice with lymphocytic choriomeningitis virus (LCMV), Naive CD8 T cells expressed a basal level of Bcl-2 that was down-regulated in effector CD8 T cells just before the death phase, Bcl-2 levels remained low during the death phase but surviving memory CD8 T cells expressed higher levels of Bcl-2 than naive cells. These changes were shown to occur in LCMV TCR transgenic cells as well as virus-specific CD8 T cells in C57BL/6 and BALB/c mice identified by MHC class I tetramers, In all instances, memory CD8 T cells expressed higher levels of Bcl-2, suggesting that increased Bcl-2 expression plays a role in the long-term maintenance of memory CD8 T cells in vivo.
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