期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 10, 期 8, 页码 767-770出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0960-894X(00)00080-9
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XTen new structures of a series of the title compounds were synthesized and screened for their activity to inhibit choline kinase under ex vivo conditions. Their inhibitory potency correlates with the C-13 chemical shifts (in CD3OD) of the methylene group bearing the positively charged nitrogen. The inhibitory effect on proliferation against the HT-29 cell line is strongly dependent on its ability to inhibit the production of phosphorylcholine. (C) 2000 Elsevier Science Ltd. All rights reserved.
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