期刊
BIOMARKERS
卷 19, 期 8, 页码 684-692出版社
INFORMA HEALTHCARE
DOI: 10.3109/1354750X.2014.981293
关键词
Coronary heart disease; coronary intermediate lesion; fractional flow reserve; intravenous ultrasound; platelet-derived microparticles
资金
- Leading Academic Discipline Project of Beijing Education Bureau [2011CB503900]
- Beijing Natural Sciences Foundation [7122200]
- National Natural Science Foundation of China [81170101, 81370235, 7122106]
This study was to investigate the utility of platelet-derived microparticles (PMPs) to detect coronary intermediate lesions. Fifty-two patients with coronary intermediate lesions and 24 subjects with normal coronary arteries were enrolled. In the former group, 31 patients accepted both intravenous ultrasound (IVUS) and fractional flow reserve (FFR). Results showed that the level of PMPs was significantly higher in the intermediate lesion group and PMPs titer was positively correlated with thromboxane B2, platelet activating factor, endothelin-1, and neutrophil to lymphocyte ratio. The level of PMPs also increased after IVUS/FFR, suggesting platelet activation and endothelial dysfunction.
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