期刊
BIOMARKERS
卷 18, 期 5, 页码 399-405出版社
INFORMA HEALTHCARE
DOI: 10.3109/1354750X.2013.798745
关键词
Colorectal cancer; DNA methylation; early diagnosis; sensitivity and specificity; serum
资金
- National Medical Research Council, Singapore
Objective: To identify methylated genes in serum with diagnostic potentials for early colorectal cancer (CRC). Methods: Serum methylation levels of up to 12 genes were measured in two sets of serum samples with the second set from 26 stage I CRC patients and 26 age/gender-matched controls. Results: Serum methylation levels of TAC1, SEPT9, and EYA4 were significant discriminants between stage I CRC and healthy controls. Combination of TAC1 and SEPT9 rendered 73.1% sensitivity with 92.3% specificity. Conclusion: Serum methylation levels of TAC1, SEPT9 and EYA4 may be useful biomarkers for early detection of CRC though a validation study is necessary.
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