期刊
BIOMARKERS
卷 17, 期 2, 页码 104-110出版社
INFORMA HEALTHCARE
DOI: 10.3109/1354750X.2011.614961
关键词
Tumor markers; microRNA-421; gene diagnosis; circulating tumor cells; gastric cancer
资金
- Natural Science Foundation of Ningbo [2010A610044]
- Zhejiang Provincial Research Project [2010C33112]
- National Natural Science Foundation of China [30872420]
- Scientific Research Foundation of Graduate School of Ningbo University [G10JA026]
- Excellent Dissertation Foundation of Ningbo University [201014]
- Scientific Innovation Team Project of Ningbo [2011B82014]
- Ningbo University
The detection of circulating tumor cells (CTCs) has recently received great attention. To evaluate if miR-421 could be used as a specific marker for CTCs, the level of miR-421 in mononuclear cells (MNCs) from peripheral blood were determined by reverse transcription-polymerase chain reaction. Transfection of miR-421 inhibitor significantly suppressed tumor growth in vivo. The level of miR-421 in MNCs from gastric cancer was significantly higher than in those from healthy controls. The area under the receiver operating characteristic curve was 0.773 +/- 0.0736. In conclusion, miR-421 may be used as a biomarker for monitoring CTCs in patients with gastric cancer.
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