期刊
BIOMARKERS
卷 16, 期 -, 页码 S11-S21出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/1354750X.2011.587893
关键词
Systemic inflammation; sepsis; endothelial dysfunction; biomarkers; intensive care
The endothelial integrity, as mechanical barrier against microorganisms and as natural anticoagulant, is crucial for physiologic organ function. Systemic activation of the endothelium upon inflammation, sepsis, and septic shock is always ending in blood-tissue barrier disruption. With increasing dysfunction, uncontrolled clotting activation, capillary microthrombi formation, tissue edema, local hypoxia, and ischemia are initiated. This in turn enhances a vicious circle leading to multiple organ failure and death. Therefore, biomarkers reflecting this special compartment may help in the early detection of systemic inflammation and its complications. This review provides an overview of the most important endothelial biomarkers and their possible use in sepsis.
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