期刊
BIOMARKERS
卷 15, 期 8, 页码 663-670出版社
INFORMA HEALTHCARE
DOI: 10.3109/1354750X.2010.509811
关键词
Obesity; SHBG; insulin; liver enzymes; white blood cells
资金
- US Army Medical Research and Materiel Command [DADM17-01-1-0417]
- National Institute of Health (NIH), National Center for Research Resources [M01-RR-00073, 1UL1RR029876-01]
- National Institute of Health (NIH), National Cancer Institute [CA95545, CA65628]
- National Institute of Health (NIH), National Institute of Environmental Health Sciences [ES006676]
C-reactive protein (CRP) is considered a marker of inflammation, which is a risk factor for many chronic diseases. However, determinants of CRP remain unclear and were studied in a strictly defined cohort of healthy premenopausal women (n=233) using multiple regression models. Independent predictors of serum CRP (model R(2)=0.59) were percentage body fat, serum alkaline phosphatase (ALP), sex hormone-binding globulin and white blood cell count. The close association between CRP and ALP suggests that enzymatic activity of ALP may be important for the anti-inflammatory effects of CRP, which should be confirmed with additional studies.
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