期刊
BIOMARKERS
卷 15, 期 4, 页码 332-339出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/13547501003706558
关键词
Acute kidney injury; biomarker; cardiopulmonary bypass; kidney injury molecule-1 (Kim-1); interleukin-18 (IL-18)
资金
- Guangdong Natural Science Foundation [9151170003000015]
The aim of this nested case-control study was to assess the combined use of urinary kidney injury molecule (KIM)-1 and interleukin (IL)-18 for acute kidney injury (AKI) after cardiopulmonary bypass surgery (CPB). From a cohort of 122 subjects who underwent CPB, serial urinary KIM-1 and IL-18 concentrations were determined in 30 AKI and 92 non-AKI patients. An increased level of urinary KIM-1 was associated with the occurrence of AKI, whereas an increased level of IL-18 was related to progressive AKI. The combination of these two biomarkers facilitates the early diagnosis and assessment of the likely progression of AKI after CPB.
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