期刊
BIOMARKERS
卷 15, 期 5, 页码 470-474出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/1354750X.2010.485332
关键词
Cervical cancer; HPV; AKNA; AT-hook motif; SNPs; risk factor; RFLP
资金
- Instituto Nacional de Salud Publica
- SEP-CONACyT [46151]
- CONACyT
The AKNA gene is part of the 9q32 susceptibility locus for cervical cancer. A single-nucleotide polymorphism at codon 1119 of AKNA, yields a biologically relevant amino acid change (R1119Q) at the DNA binding AT-hook motif. Genotype frequencies in 97 allele pairs were: R/R = 0.597, R/Q = 0.278, Q/Q = 0.123. Q/Q homozygosity was present in 8.33% of healthy controls, 16.67% of patients with cervical intraepithelial neoplasia and 75% of cervical cancer patients. These differences are highly significant for the presence of Q/Q in cervical cancer (p = 0.01, odds ratio 3.66, 95% confidence interval 1.35-9.94). Therefore, AKNA appears to be an important genetic factor associated with the risk cervical cancer.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据