期刊
BIOMARKERS
卷 14, 期 8, 页码 596-603出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/13547500903183962
关键词
Autism spectrum disorder; indolyl-3-acryloylglycine; gastrointestinal disturbance; diagnosis; urinary biomarker; subtypes
An autism spectrum disorder (ASD) diagnosis is based on clinical behaviours as there are no validated biological diagnostic tools. Indolyl-3-acryloylglycine (IAG) is a chemical produced by gut microflora and there are conflicting reports as to whether urinary levels are elevated in children with ASD compared with controls. Urinary IAG levels in morning urine samples were statistically significantly higher in children with ASD whose caregivers reported the presence of chronic gastrointestinal (GI) disturbance than children with ASD without chronic GI disturbance. Urinary IAG, however, was not statistically significantly higher in children with ASD, compared with siblings or unrelated controls without ASD.
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