期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 122, 期 16, 页码 3830-3838出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja994285v
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The total synthesis of the novel immunosuppressant sanglifehrin A (SFA, 1) is described. The approach is flexible, convergent, and stereoselective. The use of Paterson's aldol methodology was pivotal fur the preparation of the novel, highly substituted spirolactam fragment of SFA. The 22-membered macrocyclic core of the molecule and the coupling of this fragment to the spirolactam moiety were successfully achieved using selective intra- and intermolecular Stille reactions, respectively. Carbodiimide-based protocols were employed for the synthesis of the tripeptide backbone.
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