期刊
BIOMARKERS
卷 14, 期 1, 页码 3-16出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/13547500902730672
关键词
Manganese; iron; exposure assessment; Mn-Fe ratio; biomarker; saliva; erythrocyte; smelter
资金
- U. S. Department of Defense [W81XWH- 05-1-0239]
- U. S. NIH/National Institute of Environmental Health Sciences [ES-08164]
- National Natural Science Foundation of China [30760209]
- U. S. CDC/National Institute for Occupational Safety and Health [T01 OH 008615]
- NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH [T01OH008615] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [R01ES008146] Funding Source: NIH RePORTER
Unexposed control subjects (n = 106), power distributing and office workers (n = 122), and manganese (Mn)-exposed ferroalloy smelter workers (n = 95) were recruited to the control, low and high groups, respectively. Mn concentrations in saliva, plasma, erythrocytes, urine and hair were significantly higher in both exposure groups than in the controls. The Fe concentration in plasma and erythrocytes, however, was significantly lower in Mn-exposed workers than in controls. The airborne Mn levels were significantly associated with Mn/Fe ratio (MIR) of erythrocytes (eMIR) (r = 0.77, p 0.01) and plasma (pMIR) (r = 0.70, p 0.01). The results suggest that the MIR may serve as a useful biomarker to distinguish Mn-exposed workers from the unexposed, control population.
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