期刊
CELL
卷 101, 期 3, 页码 331-340出版社
CELL PRESS
DOI: 10.1016/S0092-8674(00)80842-9
关键词
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资金
- NIGMS NIH HHS [R29 GM054749-05, R29 GM54749, R29 GM054749-04] Funding Source: Medline
Plant reproduction requires precise control of flowering in response to environmental cues. We isolated a late-flowering Arabidopsis mutant, fkf1, that is rescued by vernalization or gibberellin treatment. We positionally cloned FKF1, which encodes a novel protein with a PAS domain similar to the flavin-binding region of certain photoreceptors, an F box characteristic of proteins that direct ubiquitin-mediated degradation, and six kelch repeats predicted to fold into a beta propeller. FKF1 mRNA levels oscillate with a circadian rhythm, and deletion of FKF1 alters the waveform of rhythmic expression of two clock-controlled genes, implicating FKF1 in modulating the Arabidopsis circadian clock.
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