期刊
SCIENCE
卷 288, 期 5466, 页码 675-678出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.288.5466.675
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资金
- NIAID NIH HHS [AI-17134, AI-22295, AI-18785] Funding Source: Medline
Memory T cells maintain their numbers for long periods after antigen exposure, Here we show that CD8(+) T cells of memory phenotype divide slowly in animals. This division requires interleukin-15 and is markedly increased by inhibition of interleukin-2 (IL-2), Therefore, the numbers of CD8(+) memory T cells in animals are controlled by a balance between IL-15 and IL-2.
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