期刊
CANCER LETTERS
卷 152, 期 1, 页码 23-29出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/S0304-3835(99)00428-0
关键词
spisulosine; cytoskeleton; actin stress fibers; Rho protein
类别
Spisulosine is a novel antiproliferative (antitumoral) compound of marine origin. In this work the molecular target for this toxic agent has been analyzed. In the presence of spisulosine, cultured cells change their morphology, first acquiring a fusiform morphology, and later becoming rounded without focal adhesions. Analysis of the cytoskeleton of treated cells indicate the absence of actin stress fibers. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
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