期刊
BIOMACROMOLECULES
卷 15, 期 8, 页码 2907-2913出版社
AMER CHEMICAL SOC
DOI: 10.1021/bm500518u
关键词
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资金
- National Natural Science Foundation of China [51033005, 21074121, 21090354, 51273187, 81171829]
- Fundamental Research Funds for the Central Universities [WK2060200012]
- Program for New Century Excellent Talents in Universities [NCET-11-0882]
In this study, we have prepared a self-cross-linking PEG-based branched polymer, which easily forms a bioreducible nanoshell around polyplexes of cationic polymer and DNA, simply via heating the polyplex dispersions in the presence of this self-cross-linking branched polymer. This nanoshell can prevent the polyplex from dissociation and aggregation in physiological fluids without inhibiting the electrostatic interactions between the polymer and DNA. Furthermore, glutathione (GSH) can act as a stimulus to open the nanoshell after it has entered the cell. The polyplexes coated with the bioreducible nanoshell show an obvious enhancement in gene transfection in vivo compared with bare polyplexes.
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