期刊
BIOMACROMOLECULES
卷 15, 期 5, 页码 1586-1592出版社
AMER CHEMICAL SOC
DOI: 10.1021/bm500438x
关键词
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资金
- National Natural Science Foundation of China [21074095, 21104059, 21174107, 21374080]
- Eastern Scholar Professorship
- Shanghai 1000 Plan
- New Century Excellent Talents in Universities of MOE [NCET-10-0627]
- Ph.D. Program Foundation of MOE [20110072110048]
- Fok Ying Tong Education Foundation [132018]
- fundamental research funds for the central universities
Presented in this article is the preparation of a new theranostic vesicle which exhibits excellent in vitro and in vivo T-1 magnetic resonance (MR) imaging contrast effect and good anticancer drug delivery ability. The theranostic vesicle has been easily prepared based on an amphiphilic biocompatible and biodegradable dibock copolymer, poly(ethylene glycol)-block-poly(L-lactic-co-glycolic acid) (PEG-b-PLGA) and bovine serum albumin-gadolinium (BSA-Gd) complexes. Dynamic light scattering (DLS), transmission electron microscopy (TEM), UV-vis spectroscopy, and inductively coupled plasma atomic emission spectroscopy (ICP-AES) measurements confirmed the formation and physiological stability of BSA-Gd@PEG-b-PLGA vesicles. Furthermore, the in vitro and in vivo MR imaging experiments revealed their excellent T-1-weighted MR imaging function. Red blood cell hemolysis and cytotoxicity experiments confirmed their good blood compatibility and low cytotoxicity. Doxorubicin (DOX) loading and release experiments indicated a more retarded release rate of DOX in those theranostic vesicles than sole PEG-b-PLGA nanoparticles without BSA. Overall, this new biocompatible and biodegradable vesicle shows promising potential in theranostic applications.
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