期刊
BIOMACROMOLECULES
卷 15, 期 6, 页码 2138-2145出版社
AMER CHEMICAL SOC
DOI: 10.1021/bm500313f
关键词
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资金
- National Research Foundation (NRF) of Korea [2012R1A1A2006453, 20090083522, 2013M2B2A4O41202, 2009-0066736]
- National Research Foundation of Korea [2012R1A1A2006453, 2009-0066736] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
We explore here the possibility that polypeptide chains with directional multiplicity might provide for the control of peptide self-assembly processes. We tested this new possibility using an oppositely directed peptide (ODP) supramolecular system. The ODP could make it possible to form a beta alpha beta motif with antiparallel beta-sheets, which does not exist in nature. Furthermore, the designed ODPs were able to self-assemble into discrete, homogeneous, and structured protein-like controlled nano-objects. ODPs represent a simple but powerful unnatural self-assembling peptide system that can become a basic scaffold for fabricating more complex and elaborate artificial nanostructures.
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