期刊
BIOMACROMOLECULES
卷 14, 期 7, 页码 2206-2214出版社
AMER CHEMICAL SOC
DOI: 10.1021/bm4003442
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资金
- National Natural Science Foundation of China [51073102]
- Fok Ying Tung Education Foundation [122034]
- Program for New Century Excellent Talents in University [NCET-10-0592]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT1163]
- Foundations of Sichuan Province [2012JQ0009]
- Fundamental Research Funds for the Central Universities [2010SCU22001, 2011SCU04A04]
- Natural Science Foundation of Jiangsu Province [BK2010248, BK2011340]
A series of thermoresponsive and biocompatible ABA triblock copolymers in which the outer A blocks comprise poly(N-isopropylacrylamide) and the central B block consists of O-phosphoethanolamine (PEA) grafted poly(acrylic acid) (PAA(PEA)) are achieved by atom transfer radical polymerization (ATRP) and subsequent modification. At a relatively low concentration (2 w/v% in phosphate buffered saline), the triblock copolymers can form free-standing gels at 37 degrees C. Using a combination of variable-temperature H-1 NMR, dynamic light scattering, and rheological measurements, it is demonstrated that the gelation behavior is highly dependent on both the length of A blocks and the substitution degree of phosphate group. To examine the potential application as scaffold for bone tissue engineering, the physical application as scaffold for bone tissue engineering, the physical gels are incubated in the simulated body fluid (SBF) for 2 weeks. Obvious nucleation and growth of hydroxyapatite are found in the gels, as indicated by the scanning electron microscope, energy dispersive spectroscopy, and X-ray diffraction measurements. The triblock copolymers also exhibit low cytotoxicity in cell viability test. Thus the triblock copolymers have great potential for bone tissue engineering.
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