期刊
BIOMACROMOLECULES
卷 15, 期 1, 页码 132-142出版社
AMER CHEMICAL SOC
DOI: 10.1021/bm401413c
关键词
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资金
- National Institutes of Health [R01 DE017441]
- Baylor's Scientific Training Program for Dental Academic Researchers [T32 DE018380]
- National Institute of Dental and Craniofacial Research [F31 DE023999]
- NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH [T32DE018380, R01DE017441, F31DE023999] Funding Source: NIH RePORTER
Injectable, dual-gelling hydrogels were successfully developed through the combination of physical thermogellation at 37 degrees C and favorable amine:epoxy chemical cross-linking. Poly(N-isopropylacrylamide)-based thermogelling macromers with a hydrolyzable lactone ring and epoxy pendant groups and a biodegradable diamine-functionalized polyamidoamine cross-linker were synthesized, characterized, and combined to produce nonsyneresing and bioresorbable hydrogels. Differential scanning calorimetry and oscillatory rheometry demonstrated the rapid and dual-gelling nature of the hydrogel formation. The postgelation dimensional stability, swelling, and mechanical behavior of the hydrogel system were shown to be easily tuned in the synthesis and formulation stages. The leachable products were found to be cytocompatible under all conditions, while the degradation products demonstrated a dose- and time-dependent response due to solution osmolality. Preliminary encapsulation studies showed mesenchymal stem cell viability could be maintained for 7 days. The results suggest that injectable and thermally and chemically cross-linkable hydrogels are promising alternatives to prefabricated biomaterials for tissue engineering applications, particularly for cell delivery.
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