期刊
BIOMACROMOLECULES
卷 14, 期 7, 页码 2403-2410出版社
AMER CHEMICAL SOC
DOI: 10.1021/bm400527y
关键词
-
资金
- Fundacao para a Ciencia e Tecnologia [SFRH/BD/61126/2009]
- Fundo Social Europeu
- Programa Diferencial de Potencial Humano
- EU [RE-GPOT-CT2012-316331-POLARIS, 278557, 263363]
- Health and Progress Foundation (Mobility Program for Nanomedicine)
- Andalusian Initiative for Advanced Therapies (Ministry of Health of the Andalusian Regional Government)
- MEC of the Spanish Government [MAT2012-38043-C02-01, MAT2010-15310, MAT-2010-15982, PRI-PIBAR-2011-1403, ACI2009-0890]
- JCyL [VA155A12-2, VA152A12-2, VA049A11-2]
- Network Center of Regenerative Medicine
- ISCIII
- Fundação para a Ciência e a Tecnologia [SFRH/BD/61126/2009] Funding Source: FCT
Inspired by the cells structure, we present compartmentalized capsules with temperature and magnetic-based responsiveness and hierarchical organization ranging from the nano- to the visible scales. Liquefied alginate macroscopic beads coated with a layer-by-layer (LbL) chitosan/alginate shell served as containers both for model fluorophores and microcapsules, which in their turn encapsulated either another fluorophore or magnetic nanoparticles (MNPs). The microcapsules were coated with a temperature-responsive chitosan/elastin-like recombinamer (ELR) nanostructured shell. By varying the temperature from 25 to 37 degrees C, the two-hour release of rhodamine encapsulated within the microcapsules and its diffusion through the external compartment decreased from 84% and 71%. The devices could withstand handling and centrifugal stress, with 50% remaining intact at a rotation speed of 2000g. MNPs attributed magnetic responsiveness toward external magnetic fields. Such a customizable system can be envisaged to transport bioactive agents and cells in tissue engineering applications.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据