期刊
JOURNAL OF BIOMEDICAL SCIENCE
卷 7, 期 3, 页码 200-212出版社
BMC
DOI: 10.1007/BF02255467
关键词
tolerance; cytokine; interleukins, IL-10, IL-1ra; plasticity; NMDA
资金
- NIDA NIH HHS [R01-DA-04274] Funding Source: Medline
- PHS HHS [T32A07234] Funding Source: Medline
Spinal acute opioid tolerance remains mechanistically undercharacterized. Expanded clinical use of direct spinal administration of opioids and other analgesics indicates that studies to further understand spinal mechanisms of analgesic tolerance are warranted. Rodent models of spinal administration facilitate this objective. Specifically, acute spinal opioid tolerance in mice presents a plasticity-dependent, rapid, and efficient opportunity for evaluation of novel clinical agents. Similarities between the pharmacology of acute and chronic spinal opioid tolerance, neuropathic pain, and learning and memory suggest that this model may serve as a high through-put predictor of bioactivity of novel plasticity-modifying compounds. Copyright (C) 2000 National Science Council, ROC and S. Karger AG, Basel.
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