期刊
NATURE MEDICINE
卷 6, 期 5, 页码 536-542出版社
NATURE AMERICA INC
DOI: 10.1038/75015
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资金
- NCI NIH HHS [CA7529, CA74463] Funding Source: Medline
- NIAID NIH HHS [AI37740] Funding Source: Medline
Helicobacter pylori is causally associated with gastritis and gastric cancer. Some developing countries with a high prevalence of infection have high gastric cancer rates, whereas in others, these rates are low. The progression of helicobacter-induced gastritis and gastric atrophy mediated by type 1 T-helper cells may be modulated by concurrent parasitic infection. Here, in mice with concurrent helminth infection, helicobacter-associated gastric atrophy was reduced considerably despite chronic inflammation and high helicobacter colonization. This correlated with a substantial reduction in mRNA for cytokines and chemokines associated with a gastric inflammatory response of type 1 T-helper cells. Thus, concurrent enteric helminth infection can attenuate gastric atrophy, a premalignant lesion.
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