期刊
BIOMACROMOLECULES
卷 13, 期 10, 页码 3013-3017出版社
AMER CHEMICAL SOC
DOI: 10.1021/bm301346e
关键词
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资金
- National Institutes of Health [R21 CA 137506-01]
- NIH Funded Biotechnology Training Grant [T32 GMO67555]
Oxime Click chemistry was used to form hydrogels that support cell adhesion. Eight-armed aminooxy poly(ethylene glycol) (PEG) was mixed with glutaraldehyde to form oxime-linked hydrogels. The mechanical properties, gelation kinetics, and water swelling ratios were studied and found to be tunable. It was also shown that gels containing the integrin ligand arginine-glycine-aspartic acid (RGD) supported mesenchymal stem cell (MSC) incorporation. High cell viability and proliferation of the encapsulated cells demonstrated biocompatibility of the material.
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