期刊
BIOMACROMOLECULES
卷 13, 期 10, 页码 3031-3038出版社
AMER CHEMICAL SOC
DOI: 10.1021/bm300520u
关键词
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资金
- Armed Forces Institute of Regenerative Medicine [W81XWH-08-2-0034]
- Juvenile Diabetes Research Foundation [17-2007-1063]
- National Institute of Health [DE016516, DE01323]
- MIT-Portugal Program
- Fundacao para a Ciencia e Tecnologia [SFRH/BD/35686/2007]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/35686/2007] Funding Source: FCT
Synthetic scaffolds are crucial to applications in regenerative medicine; however, the foreign body response can impede regeneration and may lead to failure of the implant. Herein we report the development of a tissue engineering scaffold that allows attachment and proliferation of regenerating cells while reducing the foreign body response by localized delivery of an anti-inflammatory agent. Electrospun fibers composed of poly(L-lactic) acid (PLLA) and poly(epsilon-caprolactone) (PCL) were prepared with and without the steroid anti-inflammatory drug, dexamethasone. Analysis of subcutaneous implants demonstrated that the PLLA fibers encapsulating dexamethasone evoked a less severe inflammatory response than the other fibers examined. They also displayed a controlled release of dexamethasone over a period of time conducive to tissue regeneration and allowed human mesenchymal stem cells to adhere to and proliferate on them in vitro. These observations demonstrate their potential as a building block for tissue engineering scaffolds.
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