期刊
BIOMACROMOLECULES
卷 13, 期 4, 页码 952-962出版社
AMER CHEMICAL SOC
DOI: 10.1021/bm2018118
关键词
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资金
- Academy of Sciences of the Czech Republic (Institutional Research Plans) [AV0Z50390703, AV0Z50390512]
- Ministry of Education, Youth, and Sports of the Czech Republic [NPV II 2B06130, 1M0510, MSM0021620849, 4977751303]
- Grant Agency of the Academy of Sciences [IAA500390702]
- Czech Science Foundation [GA202/09/1151, P304/10/1307]
- Charles University [96610, 80009, 97110, 330611, 384311, 164010]
- Grant Agency of the Czech Republic [106/09/P226]
- Ministry of Health of the Czech Republic [NT12156]
- Ministry of Education of the Czech Republic [ME 10145]
The broader application of liposomes in regenerative medicine is hampered by their short half-life and inefficient retention at the site of application. These disadvantages could be significantly reduced by their combination with nanofibers. We produced 2 different nanofiber-liposome systems in the present study, that is, liposomes blended within nanofibers and core/shell nanofibers with embedded liposomes. Herein, we demonstrate that blend electrospinning does not conserve intact liposomes. In contrast, coaxial electrospinning enables the incorporation of liposomes into nanofibers. We report polyvinyl alcohol-core/poly-epsilon-caprolactone-shell nanofibers with embedded liposomes and show that they preserve the enzymatic activity of encapsulated horseradish peroxidase. The potential of this system was also demonstrated by the enhancement of mesenchymal stem cell proliferation., In conclusion, intact liposomes incorporated into nanofibers by coaxial electrospinning are very promising as a drug delivery system.
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