Synthesis, Characterization, and Paclitaxel Release from a Biodegradable, Elastomeric, Poly(ester urethane)urea Bearing Phosphorylcholine Groups for Reduced Thrombogenicity

Biodegradable polymers with high elasticity, low thrombogenicity, and drug loading capacity continue to be vascular grafts and stents. A biodegradable elastomeric polyurethane was designed as a candidate material for use as a drug eluting stent coating, such that it was nonthrombogenic and could provide antiproliferative drug release to inhibit smooth muscle cell Proliferation. A phosphorylcholine containing poly(ester urethane) urea '(PEUU-PC) was synthesized grafting aminated Phosphorylcholine onto backbone carboxyl groups of a polyurethane,(PEUU-COOH). synthesized from a:so segment blend of-polycaprolactone and dimethylolpropionic: acid, a hard segment of diisocyanatobutane and a putrescine chain extender. Poly(ester urethane) urea (PEUU) from a soft segment of polycaprolactone alone was employed as a control material. An of the Synthesized polyurethanes showed high distensibility (>600%), and tensile strengths in the 20-35 MPa range. PEUU-PC experienced greater degradation than PEUU or PEUU-COOH in either a saline or lipase enzyme solution. PEUU-PC also exhibited markedly inhibited ovine blood platelet deposition compared with PEUU-COOH and PEUU. Paclitaxel loaded in all of the polymers during solvent casting continued to release for 5 d after a burst release in a 10% ethanol/PBS solution, which was utilized to increase the solubility of the releasate. Rat smooth muscle cell proliferation was significantly inhibited in 1 wk cell culture when releasate from the paclitaxel-loaded films was present. Based on these results, the synthesized PEUU-PC has promising functionality for use as a nonthrombogenic, drug eluting coating on metallic vascular stents and grafts.