期刊
BIOMACROMOLECULES
卷 13, 期 1, 页码 84-91出版社
AMER CHEMICAL SOC
DOI: 10.1021/bm201588m
关键词
-
资金
- A*STAR
- ERC
- Walters-Kundert Foundation
- Marie Curie Intraeuropean Fellowship
- Engineering and Physical Sciences Research Council [EP/F035535/1] Funding Source: researchfish
- EPSRC [EP/F035535/1] Funding Source: UKRI
The synthesis of a supramolecular double hydrophilic block copolymer (DHBC) held together by cucurbit[8]uril (CB[8]) ternary complexation and its subsequent self-assembly into micelles is described. This system is responsive to multiple external triggers including temperature, pH and the addition of a competitive guest. The supramolecular block copolymer assembly consists of poly(N-isopropylacrylamide) (PNIPAAm) as a thermoresponsive block and poly(dimethylaminoethylmethacrylate) (PDMAE-MA) as a pH-responsive block. Moreover, encapsulation and controlled drug release was demonstrated with this system using the chemotherapeutic drug doxorubicin (DOX). This triple stimuli responsive DHBC micelle system represents an evolution over conventional double stimuli responsive covalent diblock copolymer systems and displayed a significant reduction in the viability of HeLa cells upon triggered release of DOX from the supramolecular micellar nanocontainers.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据