期刊
BIOMACROMOLECULES
卷 12, 期 11, 页码 4162-4168出版社
AMER CHEMICAL SOC
DOI: 10.1021/bm201303r
关键词
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资金
- FCT (Fundacao para a Ciencia e Tecnologia)
- POPH/FSE [SFRH/BPD/63250/2009]
- Fundação para a Ciência e a Tecnologia [SFRH/BPD/63250/2009] Funding Source: FCT
Biocellulose (BC) is a highly pure form of cellulose, produced in the form of a swollen membrane, with several applications in the biomedical area. In this study, the behavior of BC membranes as systems for topical delivery of lidocaine was evaluated. The BC-lidocaine membranes were prepared and characterized in terms of structural and morphological properties. A uniform distribution of the drug inside the BC membranes was observed. In vitro diffusion studies with Franz cells were conducted using human epidermal membranes and showed that the permeation rate of the drug in BC membranes was slightly slower than that obtained with the conventional systems, which was attributed to the establishment of interactions between the lidocaine molecules and the BC membrane, as evidenced by FTJR and NMR analysis. These results indicate that this methodology can be successfully applied for the dermal administration of lidocaine regarding the release profile and ease of application.
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